WARNING:
JavaScript is turned OFF. None of the links on this concept map will
work until it is reactivated.
If you need help turning JavaScript On, click here.
This Concept Map, created with IHMC CmapTools, has information related to: Pharmacokinetics & Pharmacodynamics, Affected by pH*, Elimination Clearance (CL), First-Pass effect* can be avoided by Inhaled, Dose-concentration relationship* Distribution, First-Pass effect* can be avoided by Buccal, First-Pass effect* can be avoided by Intramuscular, Can be multiple compartments (ie plasma and tissue) Drug first enters the plasma, Pharmacokinetics Dose-concentration relationship*, Affected by Dosage form*, First-Pass effect* can be avoided by Vaginally, Dose-concentration relationship* Elimination, Maintenance dose Amount of drug needed to maintain a desired plasma concentration for a particular therapeutic effect, First-Pass effect* can be avoided by Sublingual, The ability of the body to eliminate the drug Equals <math xmlns="http://www.w3.org/1998/Math/MathML"> <mrow> <mtext> CL = </mtext> <mfrac> <mtext> Rate of elimination </mtext> <mtext> C </mtext> </mfrac> </mrow> </math>, First-Pass effect* can be avoided by Intrathecal (into the CSF), Affected by Lipophilic vs. hydrophilic*, First-Pass effect* can be avoided by Intraosteal (into the bone), First-Pass effect* can be avoided by Intravenous, Distribution Volume of distribution (V), Tissue binding vs. plasma protein binding Decreased tissue binding means that more of the drug will be in the plasma, which reduces the volume of distribution. Less drug is needed to reach the same plasma concentration.